[ Home | Weather | Wiki | HN | RSS | xkcd ] [ Search | Settings | About ] [ Light | Dark ]

3-Iodotyrosine

---

[ Related articles | Random article | Source site ]

3-Iodotyrosine is an intermediate in the synthesis of thyroid hormones which is derived from iodination of tyrosine at the meta-position of the benzene ring. One unit can combine with diiodotyrosine to form triiodothyronine, as occurs in the colloid of the thyroid follicle. Two units can combine to form 3,3'-diiodothyronine.

3-Iodotyrosine is a reversible inhibitor of the enzyme tyrosine hydroxylase.


Image gallery

---

Relevance in dopamine studies

---

3-Iodotyrosine, a pathway inhibitor in the synthesis of the neurotransmitter dopamine, was used to determine the effects of decreased dopamine levels in social spacing of Drosophila melanogaster. 3-4 day old flies that were fed 3-iodotyrosine for 24 hours were shown to have altered dopamine levels.

Search Wikipedia

---

Wikipedia is available under the Creative Commons Attribution-ShareAlike License 3.0.
These pages best viewed with Netscape Navigator 1.1 or later.
Privacy policy and session data management.